9 Calcium D Glucarate FAQ: Important Information & Side Effects

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Calcium D Glucarate is an antioxidant that helps prevent the formation of cancer cells – it inhibits the activity of a group of enzymes called beta-glucuronidases, which somewhat creates carcinogenic substances.

Calcium D Glucarate has many benefits for your health, but it can have some side effects if taken incorrectly.

In this blog post, we will discuss what calcium d glucarate is, how much to take, and when to take it correctly – so you can reap all its benefits without any side effects!

In this article:

  1. ​​What Is Calcium D Glucarate
  2. Glucaric Acid | D Glucaric Acid
  3. How Does the Body Get Rid of Toxins
  4. How Does Calcium D Glucarate Work
  5. Calcium D Glucarate Benefits | What Is Calcium D Glucarate Used For
  6. Calcium D Glucarate for Men
  7. When to Take Calcium D-Glucarate
  8. How Much Calcium D Glucarate Should I Take
  9. Calcium D Glucarate Side Effects

Related: Key Health Benefits of Diindolylmethane + Estrogen Detoxification


Calcium D Glucarate

What Is Calcium D Glucarate

Calcium D-glucarate is a calcium salt of D-glucaric acid – an acid – that humans and other animals create in traces.

Glucaric acid is produced within the human body and is in many fruits and veggies, particularly oranges, apples, grapefruit, and cruciferous veggies.

When converted into glucaric acid – Calcium D Glucarate helps the liver clear our toxins – this improves phase ii liver detox as it allows the removal of fat-soluble compounds like pesticides and other toxic chemicals [ 16, 17, 18 ].

When taken orally, Calcium-D-glucarate inhibits beta-glucuronidase – an enzyme made by colonic microflora (the bacteria in our gut).

Elevated beta-glucuronidase activity correlates to the risk of several cancers, especially breast cancer, prostate cancer, and colon cancer.

Oral calcium-D-glucarate can also regulate estrogen metabolism as a lipid-lowering medication.

Calcium D-glucarate is a natural supplement that can treat illnesses such as cancer, heart disease, and diabetes – it combines the power of calcium with glucaric acid for an excellent therapeutic effect on your cells!


Calcium glucarate is absorbed in the small intestine and changed into a molecule that inhibits beta-glucuronidase, allowing for potentially enhanced elimination of toxic.

Calcium Glucarate Common Names

  • Glucarate
  • Calcium-D-Glucarate
  • Calcium Saccharate
  • Calcium-D-Saccharate
  • Calcium D-Glucarate
  • Calcium Glucarate


D-Glucarate not only inhibits cell growth and inflammation. It also causes apoptosis in the body – which is necessary for preventing cancer. Apoptosis is the body's natural defense mechanism that destroys useless cells and removes damaged ones that are no longer useful.

D- Supplementation with D-glucarates strengthens the body's natural defenses against carcinogens and tumor promoters and their effects.

Calcium D Glucarate binds with glucuronic acid (a type of sugar), which helps the body get rid of toxins, including excess estrogen. When Calcium D Glucarate binds with glucuronic acid, it forms a compound called Calcium D Glucarate, which is soluble in water. It inhibits the absorption of fats and fat-soluble vitamins A, E, and K.

Glucaric Acid | D Glucaric Acid

D-glucaric acid is a type of calcium D-glucarate – for preventing breast, prostate, and colon cancer and removing cancer-causing chemicals, poisons, and steroid hormones from the body.

D-glucaric acid, commonly known as DGA, is a type of glucaric acid – used in the pharmaceutical industry. It's utilized as an antineoplastic medication to prevent neoplasms from developing. Antineoplastic medicines are drugs used to treat cancer.

How Does Calcium D-Glucarate Work in the Body?

Your liver does a difficult task for you every day. Even if you don't touch alcohol or work in industries that expose you to harsh chemicals, the pollutants you breathe, eat, drink, and even apply to your skin put pressure on your liver. These chemicals may begin to impact your energy and performance over time. Even low levels of environmental pollutants can affect your hormone balance and make it hard for you to slim down.

Calcium-d-glucarate can lower LDL cholesterol and eliminate pollutants and excess estrogen to help those overweight (or previously obese) battle heart disease. Excess estrogen may be harmful to individuals of all sizes, but it is especially problematic for those obese (or formerly obese).

How Does the Body Get Rid of Toxins

One of the ways the body gets rid of toxins is through a process called conjugation. Conjugation removes toxins from the body by converting them into water-soluble compounds. Glucuronides are the water-soluble derivatives formed during conjugation.

Glucuronides are water-soluble – so they may be excreted through the poop or urine. However, excessive levels of an enzyme called beta-glucuronide can slow it down. Betaglucuronide enzyme takes toxins away from their conjugate bond and makes them absorbable again by the body.

Calcium D Glucarate Benefits

  • Inhibits the absorption of fats and fat-soluble vitamins A, E, and K
  • Helps detoxification
  • Regulates blood sugar levels

Calcium D Glucarate is Used for:

  • Prevention of breast, prostate, and colorectal cancer
  • Body Detoxification by eliminating cancer-causing chemicals, poisons, and steroid hormones.

NOTE: There isn't enough evidence to support it. More evidence is needed to rate the effectiveness of calcium D-glucarate for these uses. Here's a summary of where the study on this supplement is at present.

Calcium D Glucarate for Cancer Prevention

According to a study, Rats exposed to carcinogens and given calcium glucarate – had delayed development of cancer and fewer tumors – than rats not fed calcium glucarate.

Positive findings in animal studies, on the other hand, do not always indicate that a similar approach will be effective in humans. While Calcium Glucarate demonstrated anti-cancer properties in lab tests, it is not yet proven to cure or prevent cancer in humans. There have been no evaluations yet conducted with humans for these effects.

Calcium glucarate also aids in the removal of estrogen from the body – which may help reduce estrogen levels – this might be beneficial for estrogen-sensitive breast cancer patients since it inhibits additional estrogen production.

What Types of Cancer Does Calcium D-Glucarate Help Prevent?

Laboratory and animal research indicates that calcium D-glucarate may help prevent:

  • Breast Cancer Reduction of estrogen levels caused by taking calcium D-glucarate might help protect against hormone-sensitive tumors such as breast cancer. However, human studies are needed to confirm this.
  • Prostate Cancer Some researchers believe that D-glucarate helps reduce prostate-specific antigen (PSA) levels – a protein often found in high concentrations in men with prostate cancer. More evidence is needed to support this claim.
  • Colon Cancer Laboratory studies suggest that calcium D-glucarate may help reduce the risk of colorectal cancer by preventing toxins from being reabsorbed into the intestine. Again, human trials are needed to confirm this.
  • Lung Cancer The potential anti-inflammatory and apoptotic effects of calcium D-glucarate on lung tumors warrant further study.
  • Skin Cancer There is some evidence that calcium D-glucarate can help prevent skin cancer.

A 2007 study published in the Journal of Environmental Pathology, Toxicology, and Oncology revealed that treating mice with calcium D-glucarate helped suppress the formation of skin cancer by causing apoptosis.

Calcium D-glucarate has potential as an anti-cancer therapy, but there are currently no clinical trials examining its usage in any disease treatment. Please consult your doctor before starting any new supplements.

Calcium D Glucarate Estrogen

When the body perceives stress, the hormonal circuit—consisting of the adrenals, reproductive organs, and thyroid—revs up to produce their respective hormones. When the body is overly stressed, the hormonal circuit can become imbalanced.

Estrogen dominance is part of the hormonal circuit in the NeuroEndoMetabolic (NEM) stress response. Excessive estrogen levels in women – correlates to increased allergies, PMS symptoms, and endometriosis. Its presence also correlates with autoimmune diseases like lupus, chronic elevated exposure to it, and endometrial cancer.

Can high estrogen cause breast cancer? Studies have shown that a woman's risk for breast cancer is related to the estrogen and progesterone made by her ovaries (known as endogenous). Being exposed for long periods or at high levels has been linked with an increased chance of getting this disease.

If you have NEM imbalance, it's almost certain that you also suffer from estrogen dominance and other hormone imbalances. Your hormone system has a connection with the rest of your body's systems. When one component of the NEM receives damage, the rest of the NEM must compensate.

In that sense, you will need recovery to balance your reproductive hormones. The best solution is to use the correct kind, combination, and dose of supplements. Calcium D-glucarate is a supplement that might lower estrogen levels and help treat hormone-dependent cancers.

Does Calcium D-Glucarate Reduce Estrogen?

If you think you have estrogen dominance, which many women do without realizing it, calcium D-glucarate might be a beneficial addition to your health regimen.

Calcium D-glucarate inhibits the enzyme that reactivates hormones your liver has already neutralized and marked for excretion, flushing excessive estrogen from your system.

Calcium D Glucarate is the best DIM ( Diindolylmethane ) Supplement for estrogen dominance that helps reduce elevated estrogens by increasing the excretion of estrogen metabolites.

Calcium D-Glucarate (CDG) is a naturally occurring substance found in foods like broccoli and cauliflower. CDG, when taken as a supplement, helps regulate the body's production of estrogen by activating an enzyme called glucaric acid.

  • You may take Calcium D-glucarate supplements daily to help keep estrogen levels in check and improve overall health.
  • When taking calcium D-glucarate supplements, it is vital to follow the dosage instructions on the product label for best results.
  • Prevent any potential side effects from taking calcium D-glucarate supplements and keep your estrogen levels balanced by taking a break from using calcium D-glucarate supplements every few months to give your body a break.
  • If you are experiencing estrogen dominance symptoms, calcium D-glucarate supplements can be a good option.

Calcium D Glucarate for Men

Calcium D-Glucarate is a supplement taken by men who are undergoing treatment for prostate cancer – to limit its progression.

Calcium D Glucarate has also been used – as part of a post-cycle therapy routine concerning anabolic steroid use.

Some people have asked whether or not they can take calcium d glucarate if they are using TRT – if considering taking the supplement, speak with their doctor first before doing so!

Check out this video of TRT Test Your Levels for the Possible TRT Benefits of Calcium D-Glucarate:

While calcium d glucarate might not be for everyone, it could help you optimize your testosterone levels if they are too high! But before taking any supplement, consult with your doctor.

Calcium D Glucarate Side Effects

Does calcium D-glucarate have any side effects?

There is little information on the side effects of calcium D-glucarate. But it is considered to be safe and well-tolerated in people.

At this time, it is not sure if calcium D-glucarate is safe for pregnant or breastfeeding women. Some potential side effects associated with calcium D-glucarate include:

  • Diarrhea
  • Nausea
  • Vomiting

Does calcium D-glucarate have side effects?

  • Decreased absorption of dietary calcium
  • Arthralgia (joint pain)

There's some concern that combining calcium D-glucarate with certain drugs subjected to glucuronidation might reduce their efficacy. Some examples of these medications are:

  • Lipitor (atorvastatin)
  • Ativan (lorazepam)
  • Tylenol (acetaminophen)

Calcium D-Glucarate Testosterone

  • Calcium D-glucarate may also reduce the amounts of other steroid hormones in the body, such as testosterone.

How Much Calcium D Glucarate Should I Take

The proper dosage of calcium D-glucarate is determined on a case-by-case basis, depending on the user's age, health, and several other factors. There isn't enough medical evidence right now to establish a suitable range of dosages for Calcium D-Glucarate.

Please note that natural products are not always necessarily safe – consider dosages carefully.

  • Before using, double-check the product's label and talk to your pharmacist, physician, or other healthcare experts.
  • Make sure to follow the instructions as directed on product labels. Consult your pharmacist or doctor before using it.

Do not use it if you are allergic to any of its components.

For casual usage, 1 500 mg capsule once a day is sometimes advised. Calcium D-Glucarate inhibits the enzyme beta-glucuronidase at doses of 1,500 mg per day and 9 grams per day. The research on calcium d-glucarate demonstrating its ability to inhibit beta-glucuronidase begins with dosages of 1,500 mg per day and goes up to 9 grams.

When Should You Take Calcium D-Glucarate?

Pure Encapsulations recommends 1-6 capsules per day, in divided doses, with meals.

Are There Any Potential Side Effects Or Precautions?

At this time, there are no known side effects or precautions. If pregnant or lactating, consult your physician before taking this product.

To learn more about Calcium D Glucarate, Check out this video:

To reap all the benefits of this powerful antioxidant, make sure to take them correctly!

Follow these guidelines and consult with your doctor if you have any questions or concerns.

Thanks for reading!

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